Synthesis of methacrylate monomers with antibacterial effects against S. mutans.

نویسندگان

  • Jingwei He
  • Eva Söderling
  • Monica Österblad
  • Pekka K Vallittu
  • Lippo V J Lassila
چکیده

A series of polymerizable quaternary ammonium compounds were synthesized with the aim of using them as immobilized antibacterial agents in methacrylate dental composites, and their structures were characterized by FT-IR, (1)H-NMR, and (13)C-NMR analysis. Their antibacterial activities against the oral bacterium Streptococcus mutans were evaluated in vitro by a Minimum Inhibitory Concentration test, and the results showed that 2-dimethyl-2-hexadecyl-1-methacryloxyethyl ammonium iodide (C16) had the highest antibacterial activity against S. mutans, and 2-dimethyl-2-pentyl-1-methacryloxyethyl ammonium iodide (C5) and 2-dimethyl-2-octyl-1-methacryloxyethyl ammonium iodide (C8) did not show any inhibition.

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عنوان ژورنال:
  • Molecules

دوره 16 11  شماره 

صفحات  -

تاریخ انتشار 2011